Molecular parameters linking thyroglobulin iodination with autoimmune thyroiditis

Molecular parameters linking thyroglobulin iodination with autoimmune thyroiditis.

Increased iodide intake has been linked to the development of hypothyroidism and/or autoimmune thyroiditis in humans and animals, but the mechanisms involved remain poorly understood. Increased ingestion of iodide is likely to have pleiotropic effects on either metabolic or immunological processes. Within the latter domain, recent interest has been focused on two areas: a) the role of iodinated...

Linking iodine with autoimmune thyroiditis.

A great deal of circumstantial evidence has linked iodine with the rising incidence of autoimmune thyroiditis in the United States. In our investigations, we have shown directly that T cells from humans with chronic lymphocytic thyroiditis proliferate in the presence of iodinated but not in the presence of noniodinated human thyroglobulin. Moreover, the proliferative response is restored when t...

Iodination of Tyrosyls in Thyroglobulin

Cause Thyroiditis Generates Neoantigenic Determinants That Iodination of Tyrosyls in Thyroglobulin

The Properties of Thyroglobulin VIII. THE IODINATION OF THYROGLOBULIN

It has been shown that when thyroglobulin is iodinated, a marked intensification occurs in its absorption spectrum in the region of 300 to 3fXl rnp in alkaline solution (1). It is also well known that the absorption peaks of iodinated tyrosine and thyronine derivatives occur in this spectral zone (2). A procedure based on these factors has been developed which permits the simultaneous determina...